Laryngopharyngeal Reflux Symptoms Better Predict the Presence of Esophageal Adenocarcinoma Than Typical Gastroesophageal Reflux Symptoms

摘要

Many patients who develop esophageal adenocarcinoma do not report typical gastroesophageal reflux symptoms, and the majority are unaware of the presence of Barrett's esophagus prior to cancer diagnosis. This suggests that the current gastroesophageal reflux symptom-based screening paradigm is inadequate. Laryngopharyngeal reflux symptoms are more prevalent in patients that develop esophageal adenocarcinoma than typical gastroesophageal reflux symptoms, and may represent the only sign of disease. Addition of laryngopharyngeal reflux symptoms to the current screening guidelines is warranted.